Chelsea found no chink in Everton's defensive armour as the Premier League champions were held to a frustrating 0-0 draw at Goodison Park on Saturday.
Images from the FIFA World Cup qualifiers matches.
Juventus substitute Cristiano Ronaldo was denied a stoppage-time winner by VAR as Udinese came from two goals down to snatch a 2-2 draw in their thrilling Serie A season opener on Sunday.
Joao Miranda and new signing Mario Mandzukic led Atletico Madrid to a 2-1 home win in La Liga on Saturday as visitors Eibar were unable to cope with the aerial threat of the champions.
Real Madrid defender Raphael Varane made up for the absence of Sergio Ramos by scoring one goal and making another to help his side to a hard-fought 3-0 win at Getafe. La Liga leaders Barcelona were held to a 2-2 draw at struggling Espanyol on Saturday as China striker Wu Lei came off the bench to grab a late equaliser in a pulsating city derby.
Manchester City displayed champions' swagger as they roared clear at the top with a 5-0 trouncing of Burnley but it was drama which engulfed their neighbours Manchester United and Jose Mourinho that dominated the Premier League agenda on Saturday.
Liverpool had won each of their previous four home leagues games in which they conceded first and 12 minutes later they had turned another match on its head as Roberto Firmino's trickery set up Mane to give the hosts the lead at the second attempt.
Diego Costa scored twice as Atletico Madrid beat Valencia 3-0 to maintain their winning home run this season and keep pace with Barcelona at the top of the La Liga table.
AS Roma coach Rudi Garcia succeeded where his three predecessors failed by taking his team to a 2-0 win over arch-rivals Lazio on Sunday and maintaining their 100 percent record in Serie A alongside Napoli who won 2-1 at AC Milan.
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
It will have made uneasy viewing for coach Jorge Sampaoli and emphasised more than ever how reliant his side are on their talisman Messi, who has been struggling with a muscle problem.